I've lived or have spent plenty of time in all three places. Some comments:
-Panama: It's very hot and humid. Panama has limited tourist infrastructure, but they are ramping up quickly, hoping to replicate CR's success. Beachfront property is still affordable but it will be going through the roof soon. I have seen several really nice beach developments sprout up recently and plenty of gringo retirees taking interest. Apartments in Panama City are relatively expensive, but there's some development in the Canal Zone which might present opportunities.
There is definitely a strong night scene in Panama, it''s just out of the limelight. For anyone visiting I can recommend Golden Time, a massage parlor loaded with Colombianas of all shapes, sizes and quality for about $60. I'll go on the record and say that the best pro I've ever had by a long shot was in that place (and it wasn't close, it was a bachelor party, I got first pick, my buddies were jealous). There's also some semi-pro escort services which are more expensive ($100-120), but the girls were excellent. The scene in Panama is more geared towards visiting businessmen and Chinese guys, thus the higher price IMO.
For business interest, I'm not too high on Panama. Labor codes are a major hassle and Panas in general have a bad reputation for laziness.
-Nicaragua: Lived there back in 2000 and loved it. Everything is very cheap, particularly real estate. It's similar to CR twenty years ago in some parts. The political instability is always a concern, but you don't hear as much about it in Nicaragua as on the outside. I actually felt safer in Managua than in San Jose, crimewise. People in general were very friendly and a good amount of English speakers. Native food was pretty good, though the dining scene is limited. The biggest drawback is that it's still very much third world; things take forever and you have to know how to get things done. Patience, patience, patience for everything. Not as many gringos or foreigners as in CR or Panama. Also there are less creature comforts: less good restaurants, less stores (with US forwarding not a big issue), 1.5 golf courses, though the cable TV is much better. And the mongering scene is very poor. Lots of business opportunities, though, and Nicas are hard working if not very efficient.
-Costa Rica: Escazu, and the other foreigner-friendly areas of CR, offers a nice combination of third world and first world comforts. Relative security to other Lat Am countries. Generally well-educated people, though not behind the wheel of a car. Still not too expensive to enjoy service of maids, though not as cheap as other places. Golf is still affordable, though I wish the courses on the beach were closer and not so damn expensive. Improving dining scene: we're getting better variety and I think we're starting to see some better value (not great value...better tahn before). Beachfront property is going through the roof and getting there is not easy. Escazu properties are pricey but it looks like there is a glut of condos right now which could lead to some good deals, particularly if you compare it to the crazy prices in the States. In general, I'm happy to live here.
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