The other side of the coin., and a comment about crying little ones:
First off, even a ch-star-ld without any ear infection will be adversely affected by cabin pressure changes. Their little ear canals, Eustachian tubes etc. cannot accomodate changes in inner-ear pressures. The answer is to gently stroke downward on the neck below both ears, thus pulling open the ear canal a bit. I have actually demonstrated this to weary Moms with crying little ones, and mostly have been rewarded by a quieter ch*ld and a grateful Mom. Secondly, I always praise the k*ds for being good.
Sometimes it's not youngsters who are the problem. I have been repeatedly assaulted over numerous flights by inconsiderat fellow travelers, seat kickers, elbow-crowders, non-stop talkers, and the worst...people who don't give a damn about personal hygiene.

You can always ask the flight attendant to move you elsewhere (if a seat is available.
Hint: You're more likely to be moved into First or Business class if you wear a jacket and tie, good shoes, and non-denim trousers. Even if you're not flying on business, appearances matter both to the airline and to other passengers in the front of the plane.
As a last resort, you can always start a conversation like this:
"Boy, am I glad to finally be out. I'm going home to see my Mommy. Yeah, the hospital wasn't so bad...they have crats. Do you know about crafts? They let me out of my cell long enough to weave a basket (demonstrate basket weave with fingers, grinning psychotically. Allow a trickle of drool to fall from the corner of your mouth).
"Airplanes scare me. If I start to twitch, you might want to remind me to take my medications. I love my medications. The voices aren't so bad...." You get the idea. Trust me, your seat mates will get real quiet, real quickly.
